Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0010ised11 | (1) | ISED2019

Autophagy and multivesicular body formation in blastocysts during the experimental diapause in mice

Lim HJ , Shin H , Hyun Jun J , Song H

In experimentally induced diapause model in mice, blastocysts remain dormant for an extended period but resume implantation competency upon estrogen injection. The underlying mechanism by which extended longevity of dormant blastocysts is maintained is unclear. We have previously shown that dormant blastocysts, during experimentally induced diapause, exhibit heightened autophagic activation. Activation of autophagy appears to be a crucial adaptive response for survival in the ...